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The Book of 25 -THE EBOLA FACTS & MYTHS | Ebola Videos

The Book of 25 -THE EBOLA FACTS & MYTHS

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Canada’s Ebola vaccine development on a Fast Track or a Slow Boat? The Ebola conundrum continues as country after country, speeds towards the “Holy Grail” for an Ebola vaccine. The World…


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Cristoph De Caermichael says:

Canada’s Ebola vaccine development on a Fast Track or a Slow Boat?
The Ebola conundrum continues as country after country, speeds towards the
“Holy Grail” for an Ebola vaccine. The World Health Organization declared
in August that “West Africa is experiencing the largest, most severe, most
complex outbreak of Ebola virus disease in history”. That led to the WHO
convening to “consider and assess the ethical implications for clinical
decision-¬making of use of unregistered interventions that have shown
promising results in the laboratory and in animal models but that have not
yet been evaluated for safety and efficacy in humans”.
This is the crux in all recent reports on the evolution and development of
the vaccine either from Canada, the U.K or the U.S.A. While full-steam
ahead and damn the torpedoes may be the Oorah!, which constitutes the Ebola
War Cry reality does bite. The world hastens to establish, design, and
implement trial after trail of the so far elusive vaccine. The WHO predicts
a staggering 10,000 cases per week by December. A number so high, as to
instill, a fever into mankind’s previously complacent, attitude to this
current Ebola outbreak.
Health officials with the Public Health Organization in Canada are
dispensing sound bites of “Hope” the wish to be first in establishing the
vaccine. Dr. Lindsay Elmgren, Director, Centre for Biologics Evaluation,
Health Canada and Head, of the WHO Collaborating Centre for Standardization
and Evaluation of Biologics affirmed, “The Ebola disease is very serious
and cases will very likely reach the numbers that WHO predicts. Having said
that, the risk to Canadians remains low”. He continued, “There are
currently no licensed or approved Ebola vaccines. There are 2 candidate
vaccines that are currently undergoing Phase 1 clinical trials in the US,
Britain, and Germany. All further use of these vaccines will depend on the
results of these trials.
One of these possible vaccines was developed by scientists working for the
Public Health Agency of Canada” Elmgren, clarified that the proverbial race
was to gain momentum against the viral contamination. “Experts around the
world are working together in an unprecedented manner to deal with the
Ebola crisis. The race to get a vaccine is against the disease, not the
experts working together.”

Canada has pledged 65 Million dollars thus far to the Ebola campaign as run
by the WHO and the need to establish groundbreaking protocols and procedure
go beyond the development of the Vaccine. In the past few days, Canada has
approved the implementation of Ebola screening and Front line protection in
5 Hospitals across Canada. Yet, Hedy Fry, PC, MP a Canadian politician and
physician, stated in regards to fighting Ebola, “Canada is not doing
enough”.
The question begs itself, what precisely is enough? Once again, Dr. Elmgren
elaborates on the prototype vaccine, “This experimental vaccine was
developed in Canada. A vaccine cannot be licensed anywhere until clinical
trials have been completed that show the product is safe and effective. As
you know, these trials have only just recently begun for the PHAC developed
vaccine.”
This may be the beginning of establishing, what is enough. “The Public
Health Agency of Canada (PHAC) has only developed one Ebola vaccine, which
is a VSV-EBOV recombinant. The marketing rights for this experimental
vaccine have been sold to NewLInk”. The VSV vaccine is made with a
vesicular stomatitis virus, belonging to the rabies family.
The complexity of the Ebola virus outbreak results, in further scientific
explorations. Canada looks to Europe as the PHAC, Ebola vaccine, a VSV-EBOV
recombinant takes us to Germany. Dr. Stephan Becker Ph.D, is Professor at
the Institute for Virology, at Philipps University of Marburg, Germany.
Becker’s research focuses on Filoviridae that comprise Marburg and Ebola
viruses. These two related viruses cause hemorrhagic fever in humans and
non hominid primates. Fruit bats are carriers of filoviruses and can spread
the virus to humans in endemic regions of Central Africa.

As a bio-safety level 4 there are no vaccines and specific therapeutics
available, filoviruses are categorized as level 4 agents, which are
investigated under the highest safety precautions. Bio-safety level 4,
ratings deals with extremely virulent viruses and was linked and introduced
to the Ebola virus in 1976.
Specific obscure Ebola information was only recently introduced to the
public by scientists like the Becker Group as global interest in the virus
grew.

The Becker Group contributed to the understanding of transcription
replication strategies of filoviruses and is mainly interested in the
interplay between viral replication and assembly. International
correspondents in Toronto, Canada requested an interview to further clarify
his research and his plans for the Canadian vaccine. Dr. Becker responded
with “Unfortunately I am not able to answer your questions because I am
drowning in requests by National media which I hardly can satisfy”
The WHO had previously acknowledged that vaccine development is often
lengthy and costly and as Dr. Elmgren, states, “Yes, this is normally up to
a 10 year process.”
The WHO went onto stipulate that “Even under the best conditions and with
the massive efforts of many partners, a significant number of doses will
not be available until late in the first quarter of 2015”. Dr. Elmgren,
“This vaccine is not simple to produce and takes time to do. This vaccine
is produced in a biological system and involves a very complex production
process and hence the delay in getting any more vaccine produced.”
So the Full steam ahead – Fast track may indeed be a slow boat, as though
there is a theory of a 6 month compression time, to produce any vaccine the
reality is dictated by at this time by uncertain forces related to the
spread of the deadly virus, procedures of vaccine protocols and “
Lady-Luck”. Serendipity will play a role of the right place, right time and
all counter measures coming together to contain, Ebola and stop it
spreading to the Americas, including Canada and to Europe and Asia.
In the interim, the WHO says it may allow health-care workers working on
the frontlines of the epidemic to receive the Ebola vaccines even before
their effectiveness has been fully studied. Dr. Elmgren confirmed, “This
would be part of a controlled clinical trial and actually part of the
safety and effectiveness studies. Anyone receiving the vaccine would get it
only after having given informed consent.”
Canadian Health Minister Rona Ambrose may be professing wishful thinking in
her previous comments that ricocheted world-wide, NO DIRECT FLIGHTS TO
CANADA. Fortunately US President Obama was more disambiguous in his
reports. Dr. Elmgren, commented upon this scenario. If flights or countries
are placed in a state of high alert, will world travel be restricted?
“There are never any guarantees that a therapeutic intervention will work
… that’s why clinical trials are carried out. As President Obama
continues to say, there is no reason to restrict world travel”. Direct
flights do not exist but connecting flights are available via, Dubai,
Spain, France, Germany and the UK to name a few routes
Toronto has spent 2.4 Billion dollars on bringing the Pan Am games to
Canada. With Ebola seen as a long term environmental threat, can this be
perceived as a game of Russian roulette? Bringing millions of people to
Toronto at a time when Ebola vaccines are just being introduced into the
world’s population, if all goes according to some plan? Canada is bringing
the world to Toronto, creating the perfect storm for Ebola infection, as
per Ebola’s ability to infect, by close exposure. Dr. Elmgren, replies
“Interesting scenario. Ebola is not transmissible by being in the same room
as someone. It is only transmissible by direct contact with bodily fluids
of an infected, symptomatic individual.”
Interesting, can also be applied to the Nigerian Ebola situation. The WHO
recently announced Nigeria Ebola free and went on to describe how this
occurred. Nigeria had 19 laboratory-confirmed Ebola cases 7 died and 12
survived. 900 patient contacts were identified and monitored. Dr. Aileen
Marty, International Aid consultant, comments,” Furthermore, thousands of
people were screened per day at all points of entry to the country that
borders on Benin, Chad, Cameroon and Niger, with two or three suspected
cases captured per day, and taken to the isolation ward, she said.”So the
idea is not to let anybody slip through who was either coming or going with
this”. Reports indicated that the Nigerians refrained from many cultural
norms in greeting each other and removed customary physical contact, during
the Ebola vigil. The result was after 42 days of extreme vigilance on all
citizens, Nigeria was green lit as Ebola Free. Ebola may not spread by
close quarter’s exposure, but in Nigeria this practice of avoidance was
highlighted as part of the country’s act of containment.

In Nigeria, the containment for Ebola is a sophisticated multifaceted
response that took International intervention combined with nationalistic
pride. Canada’s multicultural society may prove harder to harness due to
the many possible reactions of its vastly differentiated citizenry. When
you juxtapose a crisis state on a country that basks in the relative
certainty of low risk, interpretations of this risk, may continue to be
debated and nullified. This can lead to an environmental disaster. Ebola, a
bio-safety level 4, virus is an equal opportunity killer and not limited to
matters of perception.
With this said, stated and advised by numerous international sources the
Fast Track versus the slow boat approaches to the development of the Ebola
vaccine from all its phases and trails remains an undefined grey area. Much
has to be discovered and all sources are working towards a solution
regardless of the pace, of established protocols. Who the winner is and
what route they take is not the issue per se, as all safe guidelines will
eventually be discovered and implemented. The infancy period of Ebola
vaccine evolution is more representative today as a gestational period than
actual birth. Using (VSV) vesicular stomatitis virus, a rabies virus, does
not fall under a Level 4 category contagion and may be the equivalent of
shooting blanks. Rabid Ebola fragments notwithstanding. Ebola-Time rules
the day dictating the course future events.
Cristoph De Caermichael
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