The Arbidol Story: How a Clinically Used Antiviral Drug Inhibits Hepatitis C, Ebola, and Zika Virus

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The Arbidol Story: How a Clinically Used Antiviral Drug Developed for Influenza Virus Inhibits Hepatitis C, Ebola, and Zika Virus

Globally, annual viral epidemics and outbreaks cause millions of cases of severe illness, and hundreds of thousands of deaths. There is a continuing need for development of antiviral drugs that provide effective, affordable, orally administered, and safe approaches to preventing the devastating effects of viruses that cause significant morbidity and mortality, that frequently re-emerge, and which are globally threatening.
The synthetic antiviral drug arbidol (ARB; umifenovir) was developed over 30 years ago to suppress FLU A and B viruses, and is used clinical in several countries, but not in the US. This lecture will review the history of ARB against Influenza virus and summarize data that suggest that ARB inhibits diverse viruses primarily by targeting an essential step during virus entry into cells: the fusion of virus membranes with cellular membranes.
After viewing this lecture, participants should be able to:
1. Understand the basics of Influenza, Ebola, Lassa, and Zika virus infections and disease
2. Understand the principles of enveloped virus entry into cells and how fusogenic viral glycoproteins mediate fusion of virus membranes with endosomal membranes
3. Appreciate the potential utility of leveraging Arbidol and other FDA approved drugs as novel treatments for globally prevalent and frequently recurring viruses like Influenza, Ebola, Zika, and Lassa.

Stephen J. Polyak, PhD
Research Professor, Department of Laboratory Medicine, University of Washington
Adjunct Research Professor, Departments of Global Health and Microbiology, University of Washington;
Member, Center for AIDS Research, University of Washington/Fred Hutchinson Cancer Research Center;
Affiliate Investigator, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle

01/18/19

http://uw.edu/video

Comments

Cigaret THR says:

Arbidol available 00380966668166 watssapp

Anna Shulman says:

China announced yesterday that Arbidol will be used in China to treat/prevent coronavirus!

supreme1 says:

It helps with interferons.

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